The Pittsburgh Region is the most southwestern part of Pennsylvania. It is an area rich with history and scenery, home to the metropolitan area of Pittsburgh, old industrial towns, and some of the highest elevations in the state.
- Allegheny County - the city of Pittsburgh and its immediate suburbs
- Laurel Highlands - Bedford, Cambria, Fayette, Somerset, and Westmoreland Counties
- North Pittsburgh Region - Armstrong, Beaver, Butler, Indiana, and Lawrence Counties
- South Pittsburgh Region - Washington and Greene Counties