- Alpine - Small desert university town.
- El Paso - Largest city of the region, with a uniquely Mexican culture.
- Fort Davis
- Fort Stockton
- Lajitas - Nearest town to Big Bend National Park.
- Marfa - Home of the mysterious Marfa Lights.
- Pecos - The town that brought rodeo into the world.
- Presidio - Small historic border town which provides lodging for jaunts into the mountains.
- Balmorhea State Park, north of Fort Davis. San Soloman Springs, a very large artesian well in the foothills of the Davis Mountains, offers a warm and unique place to swim or scuba dive. Camping and motel-like lodging is available.
- Big Bend National Park
- Big Bend Ranch State Park, east of Presidio. Just west of Big Bend National park is Texas' largest state park, with over 300,000 acres in the wilderness of the Chihuahua Desert. Horse rentals, guided jeep tours, plus rafting excursions on 23 miles of the Rio Bravo and Rio Grande rivers. At its eastern edge is Barton Warnock Environmental Education Center, which explores the range of geology and wildlife of the Chihuahuan desert.
- Davis Mountains State Park, near Fort Davis. Hiking, mountain biking, and horse riding on 4 miles of trails in Texas' largest mountain chain. The trails connect with neighboring Fort Davis State Historic Site.
- Hueco Tanks State Historic Site
- Guadalupe Mountains National Park
Recognize the Signs of Dehydration and Heat Stroke
Signs of Dehydration
Signs of Heat Stroke
Heat stroke must be treated immediately. Get the victim out of the sun, put cool water on their skin and fan their skin. Elevate their feet. Call 911 for an emergency or take them to the nearest hospital.
This region is part of the vast Chihuahuan Desert and contains some of the highest desert areas in the world, with all of Texas' highest peaks. The stark, rugged terrain is very sparsely populated, with Brewster County being home to only 6,000 people in an area bigger than Rhode Island, with two-thirds of them living in Alpine. El Paso is the only sizeable city in the region. The area has a rich historical legacy left by the Spanish settlers who came to the region in the mid-17th century, as well as that of early pioneers and traders who fought off native tribal attacks until the 1880s.
- I-10 bisects the region entering from Southwest New Mexico at El Paso and cutting across the region on its way towards San Antonio.
- I-20 branches from I-10 to hit Pecos and Midland-Odessa on its way towards Dallas.
- US 285 enters the region from Carlsbad, New Mexico to the north.
- Route 90 comes in from San Antonio via Del Rio, traversing the southern portion of the region and connecting with I-10 at Van Horn.
- Mexican Highway 16 in the Mexican state of Chihuahua hits a border crossing at Ojinaga-Presidio.
- From northern Chihuahua, Mexican Highways 2 and 45 at Ciudad Juarez connect to several border crossings at El Paso.
- Historic forts built along the Chihuahua Trail and the San Antonio-El Paso road during the middle of the 1800s.
- Spanish missions built during the 17th century Spanish colonization efforts.