Povardarie is the central region of Macedonia, along the Vardar River. It includes the country's capital and largest city, Skopje.
- Demir Kapija — home to former royal wineries, ancient ruins, and hub for surrounding mountains which offer a wide range of outdoor sports, and last but not the least mighty "Iron Gate" Canyon
- Dračevo — suburb of Skopje
- Kavadarci — town at the heart of Macedonian wine country
- Negotino — some of the best wine and rakija in the country, the town is easily accessible by Skopje-Greece highway and railway
- Skopje — the national capital; a truly multicultural city with just about any ethnicity in Balkans present, as well as almost innumerable sights from Roman, Byzantine, Ottoman, and modern times
- Veles — town on the valley of Vardar River with a rich cultural heritage and centuries-old churches
- Stobi — the most famous archaeological site in the country, Stobi has some well-preserved ruins from both pre-Roman (Paeonian and Ancient Macedonian) and Roman periods
Povardarie, forming the central stretch of Macedonia between Serbian and Greek borders, is a land of mountains, canyons, and valleys, dominated by the River Vardar, the longest river of the country.
Southern Povardarie, the region around the towns of Kavadarci and Negotino, is home to Macedonian wine country, Tikveš Plain, sharing its name with the largest winery in Southeastern Europe.