- Buffalo — the Queen City, the largest one in upstate New York
- Akron — a small rural village that's home of the majestic Akron Falls
- Alden — countrified charm at the eastern edge of Erie County
- Amherst — Buffalo's most populous suburb, with a wide range of things to do; includes the charming historic village of Williamsville
- Cheektowaga — shopping galore, home of the largest mall on the Niagara Frontier
- Clarence — a comparatively-high income town known for antique shops
- Grand Island — where the Niagara River splits in two; once an old summer resort, now an upper-class exurb with a charming old-fashioned amusement park.
- Lancaster — site of the historic Lancaster Opera House
- Tonawanda — the western terminus of the present-day Erie Canal; a 19th-century lumber port turned middle-class suburb
The world-famous Niagara Falls is to the north.