The Moselle valley (Moseltal) is largely in Rhineland-Palatinate. The source of the Moselle river is in the Vosges mountains of French Alsace and it then flows north before reaching Germany at Perl and forming the border with Rhineland-Palatinate and Luxembourg.
The main airports in the region are Luxembourg Airport, IATA: LUX and Frankfurt Airport, IATA: FRA, which is about an hour's drive away. Closer are Hahn (IATA: HHN) airport and Bonn/Köln (IATA: CGN) airport which do have a number of low-cost carriers.
The A61 autobahn crosses the Moselle Valley west of Koblenz.
Avalon have a number of options of river cruises into the region.
The main road (B49, B53) runs along side the river alternating between the left and right banks.
The Moselle is one of the 13 German wine regions, the main varieties of grapes grown being Riesling and Müller-Thurgau.