Hannibal is a city in Missouri. It is located approximately 100 miles northwest of St. Louis and is located on the west bank of the Mississippi River.

Hannibal is best known as the boyhood home of author Samuel Longhorn Clemens, more commonly known as Mark Twain. Twain's The Adventures of Tom Sawyer and Adventures of Huckleberry Finn are set in Hannibal. Many historical sites in the city revolve around Twain and his writings.


Get in

By car

From the south: U.S. Route 69 or U.S. Route 71.

From the west: U.S. route 36

From the east: Interstate 72

From the north: U.S. Routes 61/24

By bus

Burlington Trailways operates daily buses in each direction between St. Louis and places in Iowa, stopping in Hannibal.

By plane

American Airlines partner Cape Air operate flights from St. Louis to nearby (28 miles away) Quincy, Illinois.

Get around




Go next

Travelers interested in the creative works of Mark Twain might also head west along U.S. Route 36 to Marceline, childhood home of another creative genius, Walt Disney.

Routes through Hannibal

St. Joseph Marceline ends  W  E  Junction to QuincyJacksonville Springfield
Burlington Fort Madison ← Junction W E  N  S  Bowling Green St. Louis

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