- Caceres — medieval town and museums
- Los Santos
- Mérida — featuring a Roman theater and Museum of Roman Art.
- Prehistoric Rock-Art Sites in the Côa Valley and Siega Verde — a UNESCO World Heritage Site near Ciudad Rodrigo and shared with Portugal
La Ruta de Isabel La Católica
If you plan on visiting the town of Guadalupe, in the Sierra de Guadalupe, you might consider hiking La Ruta de Isabel La Católica. This 17km trail starts in the nearby village of Cañamero, which can be reached by bus. The well marked trail winds it's way past beautiful lakes and stunning hills before descending into Guadalupe. The hike takes about half a day.