Central Macedonia (Κεντρική Μακεδονία) is a region of Greece.
- Chalkidiki - with its three peninsulas or Kassandra, Sithonia, Mount Athos
- Aridea — A spa town
- Edessa — The seat of the Argead dynasty and its mythical founder, Caranus of Macedonia
- Olynthos —
- Platamonas —
- Polygyros —
- Serres —
- Thessaloniki —
- Veria — The city boasts a considerable number of Byzantine monuments
- Amphipolis — Archaeological area some 60 kilometers (37 miles) from the northern city of Serres, well known for the "Lion of Amphipolis", a 4th-century BC sculpture. An ancient tomb discovered in March 2016 was likely a monument to Hephaestion, the close companion of Alexander the Great.
- Dion, Pieria — An ancient city and sanctuary dedicated to Zeus. Philip II and Alexander the Great celebrated victories in Dion.
- Litochoro — Τhe base for climbing Mt Olympus
- Pella — The birthplace of Alexander the Great
- Vergina — The ancient Aigai, the first capital of Macedonia and the place where Alexander the Great was proclaimed king, short after Philip's assassination in 336 BC.