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How to Withdraw from Methadone

Three Parts:Deciding to Quit MethadoneGetting off MethadoneStaying Off Methadone

Methadone is a synthetic opiate occasionally prescribed for chronic pain, but more often used to wean patients off of opiates like heroin. For most patients, a life-long course of methadone treatment, or maintenance therapy, is necessary to prevent relapse and return to heroin use.[1] It is helpful to think of methadone for heroin addicts as the equivalent of insulin for diabetics. Nevertheless, some patients will wish to cease using methadone. To do so, you will need to consult your doctor, seek support from a therapist and/or support group, and quit gradually, using doctor-prescribed drugs to minimize the symptoms of withdrawal.

Note: Any withdrawal program should be supervised by a suitably qualified professional. This article offers general guidance and is not a substitute for professional treatment.

Part 1
Deciding to Quit Methadone

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    Consider why you are quitting methadone. If you are taking methadone as a maintenance drug to aid in recovering from an opiate addiction, you are probably better off sticking with it. Methadone maintenance has no significant negative health effects, and patients who remain on methadone show gradual but steady improvements in health and functioning, while those who quit worsen in both regards and have a much higher tendency to relapse into opiate use.[2]
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    Speak with your physician and counselor. You will need both medical and psychological support to get off of methadone. Your doctor can tailor a withdrawal program to suit your needs. He or she can also prescribe drugs such as buprenorphine and clonidine that will greatly reduce the symptoms of withdrawal.
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    Set up a support network of friends and family. Quitting methadone is not easy. You will suffer withdrawals symptoms, and you will need to either carefully reduce your methadone intake over time or take medications regularly to substitute for methadone. Especially if you are quitting in an out-patient setting, it is extremely helpful to have friends and family who can hold you accountable and remind you to stay on course.

Part 2
Getting off Methadone

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    Do not try to quit “cold turkey.” The symptoms of methadone withdrawal are painful enough that quitting suddenly is simply not realistic. They typically begin within 30 hours of last methadone exposure and include:[3][4]
    • Early symptoms: agitation, anxiety, muscle aches, insomnia, runny nose, sweating, and yawning
    • Late symptoms: abdominal cramping, diarrhea, dilated pupils, goose bumps, nausea, vomiting
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    Be aware that quitting is a long-term process. Methadone withdrawal symptoms typically begin between 24-36 hours after the last dose and peak between 96 and 144 hours. While the detox process is usually considered over after 5-7 days, milder symptoms may last for weeks, and “abstinence syndrome” – including unease, fatigue, insomnia, and irritability – can last for up to 8 months.[5]
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    Sign up with an inpatient program if possible. Inpatient programs take less time and are up to four times as effective at achieving complete withdrawal.[6] Check here to find a clinic near you.
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    Reduce methadone use gradually. There are two methods typically used: tapering the amount of methadone used; or substituting buprenorphine and tapering or maintaining. Long-term maintenance on buprenorphine, accompanied by counseling and support groups, has been shown to produce the best rate of success.[7]
    • Rapid detox programs using naltrexone to induce withdrawal can shorten peak withdrawal symptoms to 2-3 days, but there is no evidence regarding the rates of long-term abstinence for such programs.[8]
    • Rapid detox under anesthesia should be avoided. It does not improve long-term results and carries a significant risk of death due to pulmonary edema (fluid in the lungs).[9]
    • Maintenance on naltrexone is another option. It blocks the nerve receptors that opiates use, meaning that users of naltrexone will be unable to get high on opiates. However, relapse rates are very high for naltrexone treatments.
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    Taper with methadone. There are two methods of tapering, a relatively quick method and a more recently prescribed long term method. In both cases, clonidine is often given to help reduce the symptoms of withdrawal.
    • The more traditional tapering method usually takes 5-7 weeks. Patients first rapidly reduce their use to 30 mg per day before beginning tapering at a typical rate of 5 mg per week.[10]
    • Some clinics now recommend a more drawn out tapering over 6 months to a year. The dose is reduced by 5 mg every 3 to 14 days, and then even more slowly after reaching 20 mg.[11]
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    Maintain or taper with buprenorphine-naxolone (Subuxone). Buprenorphine maintenance has been shown to be more effective than simply quitting methadone, while tapering with buprenoprhine is just as effective as tapering with methadone, and helps withdrawal symptoms to fade more quickly.[12] Patients must first reduce their methadone use to 40 mg/day for a week before beginning to substitute buprenorphine for methadone. Starting 36 hours after the last does of methadone, the oral drug buprenorphine can be used to reduce symptoms of withdrawal.[13]
    • Initial dose is 2-4 mg of buprenorphine. If that is tolerated, a second 2-4 mg does is given an hour later, and then 4 mg 6-8 hours later, for a total day 1 dose of 8-12 mg.
    • A dose of 12-16 mg is reached by day 2 or 3 and should suppress most symptoms of withdrawal from methadone, with additional symptoms treated by clonidine.
    • Once the patient’s withdrawal symptoms are stabilized, buprenorphine can be continued as a long-term maintenance drug, or can be tapered off over 2 to 3 weeks.

Part 3
Staying Off Methadone

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    Get counseling. Your doctor or the clinic you are visiting will be able to put you in touch with an experienced opiate-withdrawal counselor. Whether it is one-on-one, group, or in a family setting, counseling in conjunction with buprenorphine maintenance or detox has been shown to be much more effective than maintenance or detox alone.[14]
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    Join a support group. Support groups like Narcotics Anonymous or SMART Recovery can be extremely helpful for the recovering patient. One study found that recovering patients attending NA and AA programs had an 81% abstinence rate, compared to a 26% abstinence rate among non-attendees.[15]
    • Don't force yourself to go through the pain of methadone withdrawal alone. There are thousands of other recovering patients just like you, who can not only give you advice and support, but who draw inspiration from you.
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    Use clonidine or lofexidine to treat lingering withdrawal symptoms.[16] While clonidine is not as effective as buprenorphine during detox, it is useful in reducing lingering flu-like symptoms such as anxiety, agitation, muscle aches, sweating, runny nose, and cramping, all of which may last up to 8 months. Lofexidine is a drug with a similar pathway, recently approved in the UK, which can reduce symptoms with fewer side effects.[17]
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    Ask your doctor about using trazodone, zaleplon or zolpidem to treat insomnia. Insomnia is a common symptom of withdrawal from methodone. Zaleplon and zolpidem work like benzodiazepines such as clonazepam, but without the same withdrawal symptoms.[18] Trazodone is an anti-depressant that regulates serotonin levels, thereby aiding sleep.[19]
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    Treat the other lingering symptoms of withdrawal. Muscle cramps, diarrhea, nausea, and flu-like symptoms are most likely during detox, but such symptoms can linger for weeks. Aches and diarrhea can be treated with over-the-counter medications such as ibuprofen (Advil) and bismuth subslicylate (Pepto Bismal). Your doctor may prescribe prochlorperazine or ondanestron for nausea.[20]

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